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David Kent

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Role: 
Supervisor for Molecular Biology
Department: 
Haematology
Contact number: 
01223 762130
Contact email address: 
dgk23@cam.ac.uk
Year Joined Homerton: 
2016
Profile: 

David Kent earned a B.Sc. in Genetics and English Literature at the University of Western Ontario, Canada (1999-2003) and obtained his Ph.D. in Genetics at the University of British Columbia, Canada (2003-2009).  His postdoctoral research was at the University of Cambridge where he studied normal and malignant blood stem cell biology.  His research group studies fate choice in single blood stem cells and how changes in their regulation lead to cancers (http://www.stemcells.cam.ac.uk/researchers/principal-investigators/dr-da...). David is currently the Stem Cell Institute’s Public Engagement Champion and has a long history of public engagement and science outreach including the creation of The Black Hole, a website and blog that provides information on and analysis of issues related to the education and training of scientists.

Research Interests: 
  • Understanding how single cells are subverted to drive cancer (funded by the European Hematology Association)
  • Single cell fate choice in normal blood stem cells (funded by Bloodwise)
  • Identification of early disease biomarkers (funded by the Rosetrees Trust)
Teaching And Professional Interests: 

Academic Area/ Course Involvements

Stem cell biology, pathology, cancer biology, haematology

Prospective PhD Applications

Candidates should email Dr. Kent directly at dgk23@cam.ac.uk after visiting his research website (http://www.stemcells.cam.ac.uk/researchers/principal-investigators/dr-david-kent)

Course Involvements

Cambridge

  • Pathology 1B (2016 -present)
  • MPhil Clinical Sciences (Rare diseases )
  • Course Director Hematology 101, (Intl. Soc. of Exp. Hematology, 2016 – present),

Imperial College 

  • Ad hoc lecturer
  • Stem Cell Biology       

UBC Medical School

  • Problem Based Learning Instructor in Immunology/Hematology
Qualifications: 

Memberships:

  • 2013 – present: European Hematology Association
  • 2011 – present: International Society of Experimental Hematology
  • 2009 – present :Cambridge Cancer Centre
  • 2006 – present: International Society for Stem Cell Research

Awards:

  • 2016-2019: Rosetrees Trust  £30,000
  • 2015-2020: Bloodwise Bennett Fellowship £880,912
  • 2015-2018: European Hematology Association Non-clinical Fellowship  £188,020
  • 2011-2012: Lady Tata Memorial Trust:  Research in Leukaemia £15,000
  • 2005-2007: UBC Teaching and Learning Enhancement Fund
  • Expansion of the UBC Let’s Talk Science Partnership Program  £37,500

Scholarships:

  • 2009-2012: Canadian Institutes for Health Research (CIHR) Fellowship  £94,000
  • 2009           National Cancer Institute of Canada (NCIC) Fellowship  £82,000
  • 2006-2009  Michael Smith Foundation for Health Research (MSFHR)
  • Senior Graduate Scholarship  £16,000
  • 2006-2009  CIHR Doctoral Research Award  £41,000
  • 2005-2007  CIHR/MSFHR Transplantation Training Research Award £12,000
  • 2003-2005  Canadian Stem Cell Network Studentship £12,500
  • 2002           Natural Sciences and Engineering Research Council
  • Summer Research Award £4,300                  
  • 1999-2003  University of Western Ontario National Entrance Scholarship £12,500
Dissertation: 

Characterization of murine hematopoietic stem cells with high self-renewal activity (https://open.library.ubc.ca/cIRcle/collections/ubctheses/24/items/1.0067106)

Publications: 

Selected Publications (from 34 publications, complete list available at https://scholar.google.co.uk/citations?user=XtdJ7AMAAAAJ&hl=en):

  • *Wilson NK, *Kent DG, *Buettner F, Shehata M, Macaulay IC, Calero-Nieto FJ, Sánchez Castillo M, Oedekoven CA, Diamanti E, Schulte R, Ponting CP, Voet T, Caldas C, Stingl J, Green AR, Theis FJ, Göttgens B. Combined Single-Cell Functional and Gene Expression Analysis Resolves Heterogeneity within Stem Cell PopulationsCell Stem Cell. 2015 Jun 4;16(6):712-24.
  • Schulte R, Wilson NK, Prick JCM, Cossetti C, Maj M, Gottgens B, and Kent DG. Index-sorting resolves heterogeneous murine hematopoietic stem cell populations. Exp Hematol. 2015.
  • *Ortmann CA, *Kent DG, Nangalia J, Silber Y, Wedge DC, Grinfeld J, Baxter EJ, Massie CE, Papaemmanuil E, Menon S, Godfrey AL, Dimitropoulou D, Guglielmelli P, Bellosillo B, Besses C, Döhner K, Harrison CN, Vassiliou GS, Vannucchi A, Campbell PJ Green AR. Effect of mutation order on myeloproliferative neoplasms. N Engl J Med. 2015 Feb 12;372(7):601-12.
  • Kent, DG, Li, J, Tanna H, Fink J, Kirschner K, Pask DC, Silber Y, Hamilton TL, Sneade R, Simons BD, Green AR. Self-renewal of single mouse hematopoietic stem cells is reduced by JAK2V617F without compromising progenitor cell expansion. PLoS Biol. 2013;11(6):e1001576. doi: 10.1371/journal.pbio.1001576. Epub 2013 Jun 4.
  • Kent DG, Copley MR, Benz C, Wöhrer S, Dykstra BJ, Ma E, Cheyne J, Zhao Y, Bowie MB, Zhao Y, Gasparetto M, Delaney A, Smith C, Marra M, Eaves CJ. Prospective isolation and molecular characterization of hematopoietic stem cells with durable self-renewal potential. Blood. 2009 Jun 18;113(25):6342-50. Epub 2009 Apr 17.
  • Kent DG, Dykstra BJ, Cheyne J, Ma E, Eaves CJ. Steel factor coordinately regulates the molecular signature and biologic function of hematopoietic stem cells. Blood. 2008 Aug 1;112(3):560-7. Epub 2008 May 23.

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