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David Kent

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Role: 
Group Leader, WT/MRC Stem Cell Institute
Department: 
Haematology
Contact number: 
01223 762130
Contact email address: 
dgk23@cam.ac.uk
Year Joined Homerton: 
2016
Profile: 

David Kent earned a B.Sc. in Genetics and English Literature at the University of Western Ontario, Canada (1999-2003) and obtained his Ph.D. in Genetics at the University of British Columbia, Canada (2003-2009).  His postdoctoral research was at the University of Cambridge where he studied normal and malignant blood stem cell biology.  His research group studies fate choice in single blood stem cells and how changes in their regulation lead to cancers (http://www.stemcells.cam.ac.uk/researchers/principal-investigators/dr-da...). David is currently the Stem Cell Institute’s Public Engagement Champion and has a long history of public engagement and science outreach including the creation of The Black Hole, a website and blog that provides information on and analysis of issues related to the education and training of scientists.

Research Interests: 
  • Understanding how single cells are subverted to drive cancer (funded by the European Hematology Association)
  • Single cell fate choice in normal blood stem cells (funded by Bloodwise)
  • Identification of early disease biomarkers (funded by the Rosetrees Trust)
Teaching And Professional Interests: 

Stem cell biology, Pathology, Cancer biology, Haematology

Course Involvement:

Cambridge

  • Pathology 1B (2016 -present)
  • MPhil Clinical Sciences (Rare diseases )

Course Director                               

  • Hematology 101, (Intl. Soc. of Exp. Hematology, 2016 – present)

Imperial College                              

  • Ad hoc lecturer, Stem Cell Biology                           

UBC Medical School       

  • Problem Based Learning Instructor in Immunology/Hematology
Prospective PhD Applications: 

Candidates should email Dr. Kent directly at dgk23@cam.ac.uk after visiting his research website (http://www.stemcells.cam.ac.uk/researchers/principal-investigators/dr-david-kent)

Qualifications: 
Memberships:

2013 – present  European Hematology Association

2011 – present  International Society of Experimental Hematology

2009 – present  Cambridge Cancer Centre

2006 – present  International Society for Stem Cell Research

Awards:

2016-2019            Rosetrees Trust                                                                                        £30,000

2015-2020            Bloodwise Bennett Fellowship                                                                  £880,912

2015-2018            European Hematology Association Non-clinical Fellowship                     £188,020

2011-2012            Lady Tata Memorial Trust:  Research in Leukaemia                                £15,000

2005-2007            UBC Teaching and Learning Enhancement Fund

Expansion of the UBC Let’s Talk Science Partnership Program                                           £37,500

Scholarships:

2009-2012            Canadian Institutes for Health Research (CIHR) Fellowship                    £94,000

2009                       National Cancer Institute of Canada (NCIC) Fellowship                         £82,000

2006-2009            Michael Smith Foundation for Health Research (MSFHR)

Senior Graduate Scholarship                                                                                                £16,000

2006-2009            CIHR Doctoral Research Award                                                              £41,000

2005-2007            CIHR/MSFHR Transplantation Training Research Award                       £12,000

2003-2005            Canadian Stem Cell Network Studentship                                               £12,500

2002                       Natural Sciences and Engineering Research Council

Summer Research Award                                                                                                     £4,300                  

1999-2003            University of Western Ontario National Entrance Scholarship                 £12,500

Dissertation: 

Characterization of murine hematopoietic stem cells with high self-renewal activity (https://open.library.ubc.ca/cIRcle/collections/ubctheses/24/items/1.0067106)

Publications: 

Selected (from 34 publications, complete list available at https://scholar.google.co.uk/citations?user=XtdJ7AMAAAAJ&hl=en):

Wilson NK, Kent DG, *Buettner F, Shehata M, Macaulay IC, Calero-Nieto FJ, Sánchez Castillo M, Oedekoven CA, Diamanti E, Schulte R, Ponting CP, Voet T, Caldas C, Stingl J, Green AR, Theis FJ, Göttgens B. Combined Single-Cell Functional and Gene Expression Analysis Resolves Heterogeneity within Stem Cell PopulationsCell Stem Cell. 2015 Jun 4;16(6):712-24.

Schulte R, Wilson NK, Prick JCM, Cossetti C, Maj M, Gottgens B, and Kent DG. Index-sorting resolves heterogeneous murine hematopoietic stem cell populations. Exp Hematol. 2015.

Ortmann CA, Kent DG, Nangalia J, Silber Y, Wedge DC, Grinfeld J, Baxter EJ, Massie CE, Papaemmanuil E, Menon S, Godfrey AL, Dimitropoulou D, Guglielmelli P, Bellosillo B, Besses C, Döhner K, Harrison CN, Vassiliou GS, Vannucchi A, Campbell PJ Green AR. Effect of mutation order on myeloproliferative neoplasms. N Engl J Med. 2015 Feb 12;372(7):601-12.

Kent, DG, Li, J, Tanna H, Fink J, Kirschner K, Pask DC, Silber Y, Hamilton TL, Sneade R, Simons BD, Green AR. Self-renewal of single mouse hematopoietic stem cells is reduced by JAK2V617F without compromising progenitor cell expansion. PLoS Biol. 2013;11(6):e1001576. doi: 10.1371/journal.pbio.1001576. Epub 2013 Jun 4.

Kent DG, Copley MR, Benz C, Wöhrer S, Dykstra BJ, Ma E, Cheyne J, Zhao Y, Bowie MB, Zhao Y, Gasparetto M, Delaney A, Smith C, Marra M, Eaves CJ. Prospective isolation and molecular characterization of hematopoietic stem cells with durable self-renewal potential. Blood. 2009 Jun 18;113(25):6342-50. Epub 2009 Apr 17.

Kent DG, Dykstra BJ, Cheyne J, Ma E, Eaves CJ. Steel factor coordinately regulates the molecular signature and biologic function of hematopoietic stem cells. Blood. 2008 Aug 1;112(3):560-7. Epub 2008 May 23.

 

 

 

 

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