Having originally trained in Veterinary Medicine, Jie undertook a PhD in Infection and Immunology with Professor Ivan Morrison at the Roslin Institute in Edinburgh. The research involved the molecular characterisation of the bovine Granzyme gene family and identified a critical role of granzyme B in CD8+ T cell-mediated killing of cells infected by Theileria. Parva. This study provided the knowledge and tools that have subsequently been used to refine and enhance the immunological evaluation of T cell responses induced in vaccine trials against East Coast fever in Africa. Following this, Jie joined the group of Professor Benedict Seddon in the Francis Crick Institute Mill Hill Laboratory. Among other findings, he identified a novel function of Interleukin (IL)-7 in innate lymphoid cell (ILC)-3-dependent lymphocyte migration into lymph nodes.
To pursue his passion in lymphocyte migration and activation in cancer, Jie joined Dr. Rahul Roychoudhuri’s lab in 2018 at the Department of Pathology in Cambridge. Here his focus is on the earliest adaptive immune events that occur during cancer metastasis using mouse primary and metastatic tumour models in conjunction with cellular and molecular immunology techniques. This study will enable new insights into how adaptive immune responses primed by primary tumour deposits are recruited to metastases and provide an understanding of the influence of primary tumours on immunity to metastasis. Jie is also working on inhibitory mechanisms which restrict Treg cell activation under homeostatic conditions and during the immunosuppression responses to tumours.
Immunology, Cancer Immunology, Infection
PhD, Immunology, University of Edinburgh
BVetMed, Veterinary Medicine, China Agricultural University
British Society of Immunology
Characterization of bovine granzymes and studies of the role of granzyme B in killing of Theileria-infected cells by CD8+ T cells
Vardaka P, Lozano T, Bot C, Ellery J, Whiteside SK, Imianowski CJ, Farrow S, Walker S, Okkenhaug H, Yang J, Okkenhaug K, Kuo P and Roychoudhuri R (2020). A cell-based bioluminescence assay reveals dose-dependent and contextual 6 repression of AP-1-driven gene expression by BACH2. Scientific Reports (In press).
Grant FM*, Yang J*, Nasrallah R, Clarke J, Sadiyah F, Whiteside SK, Imianowshi CJ, Kuo P, Vardaka P, Todorov T, Zandhuis N, Patrascan I, Tough D, Kometani K, Eil R, Kurosaki T, Okkenhaug K, Roychoudhuri R (2020). BACH2 drives quiescence and maintenance of resting Treg cells to promote homeostasis and cancer immunosuppression. J Exp Med 217 (9): e20190711.
*Co-first author and co-corresponding author.
Featured in J Exp Med Special Collection of Articles on Cancer Immunology and Immunotherapy (2020).
Nasrallah R, Imianowski CJ, Bossini-Castillo L, Grant FM, Dogan M, Placek L, Kozhaya L, Kuo P, Sadiyah F, Whiteside SK, Mumbach MR, Glinos D, Vardaka P, Whyte CE, Lozano T, Fujita T, Fujii H, Liston A, Andrews S, Cozzani A, Yang J, Mitra S, Lugli E, Chang HY, Unutmaz D, Trynka G, Roychoudhuri R (2020). A distal enhancer at risk locus 11q13.5 promotes suppression of colitis by Treg cells. Nature 583(7816):447-452.
Yang J, Pemberton A, Morrison WI, and Connelley T. (2018). Granzyme B Is an Essential Mediator in CD8+ T Cell Killing of Theileria parva-Infected Cells. Infection and Immunity 87:e00386-00318.
Yang J, Vrettou C, Connelley T, and Morrison WI. (2018). Identification and annotation of bovine granzyme genes reveals a novel granzyme encoded within the trypsin-like locus. Immunogenetics 70:585-597.
Yang J, Cornelissen F, Papazian N, Reijmers PM, Llorian M, Cupedo T, Coles M, and Seddon B. (2018). IL-7–dependent maintenance of ILC3s is required for normal entry of lymphocytes into lymph nodes. J Exp Med 215:1069-1077.
Featured in J Exp Med Special Collection of Articles on Innate Lymphoid Cells (2018).
Recommended in F1000Prime, 2018; 10.3410/f.732740143.793545279.