Dr Rachel Williams
BMEDSCI MBCHB MRCPCH MD
College Lecturer and Clinical Director of Studies in Medicine
Dr Rachel Williams is a paediatric endocrinologist who has a strong record of accomplishment in research and medical education. She is employed both by Cambridge University Hospitals NHS Foundation Trust, and the University of Cambridge School of Clinical Medicine to make up a full-time position.
As a clinician, in addition to experience and training in paediatric endocrinology, she has specific interests in the management of children with syndromes of severe insulin resistance and polycystic ovarian syndrome.
Her current research projects include a clinical trial comparing the effects of 2 different basal insulins (detemir and glargine) on weight gain in adolescent girls with type 1 diabetes, and a physiological study looking at the effects of synthetic estrogen administration on hepatic growth hormone resistance and urine albumin excretion in girls with type 1 diabetes.
She has a formal role in medical education with responsibility for the delivery of the final MB examination in Paediatrics, which is delivered to students at the end of stage 2, and am also a member of the Clinical Communication Skills team.
Paediatric Endocrinology and Diabetes, Clinical Communication
Willemsen, R.H., D. Elleri, R.M. Williams, K.K. Ong and D.B. Dunger, Pros and cons of GnRHa treatment for early puberty in girls. Nat Rev Endocrinol, 2014. 10(6): p. 352-63.
Simpkin, A., E. Cochran, F. Cameron, M. Dattani, M. de Bock, et al., Insulin Receptor and the Kidney: Nephrocalcinosis in Patients with Recessive INSR Mutations. Nephron Physiol, 2014.
Atherton, R., A. Ross, F. Jessop, R. Williams, R. Heuschkel, et al., Coeliac disease in children with type 1 diabetes: are current guidelines proving difficult to implement in practice? J Pediatr Gastroenterol Nutr, 2014. 59(5): p. 600-3.
Williams, R.M., K.K. Ong and D.B. Dunger, Polycystic ovarian syndrome during puberty and adolescence. Mol Cell Endocrinol, 2013. 373(1-2): p. 61-7.
Thankamony, A., P.H. Tossavainen, A. Sleigh, C. Acerini, D. Elleri, et al., Short-term administration of pegvisomant improves hepatic insulin sensitivity and reduces soleus muscle intramyocellular lipid content in young adults with type 1 diabetes. J Clin Endocrinol Metab, 2013. 99(2): p. 639-47.
Prentice, P. and R.M. Williams, Disorders of Puberty. Medicine, 2013. 41(10): p. 604-606.
Harper, R.L., R.A. Breene, M. Gattens, R.M. Williams and M.J. Murray, Non-irradiated female survivors of childhood acute lymphoblastic leukaemia are at risk of long-term increases in weight and body mass index. Br J Haematol, 2013. 163(4): p. 510-3.
Bluck, L., R. Williams, S. Jackson, B. Salgin, C. Acerini, et al., Insulin sensitivity assessed by stable isotopes with oral glucose administration: validation with euglycaemic clamp. ISRN Endocrinol, 2013. 2013: p. 189412.
Williams, R.M., C.E. Ward and I.A. Hughes, Premature adrenarche. Arch Dis Child, 2011
Breene, R.A., R.M. Williams, J. Hartle, M. Gattens, C.L. Acerini, et al., Auxological changes in UK survivors of childhood acute lymphoblastic leukaemia treated without cranial irradiation. Br J Cancer, 2011. 104(5): p. 746-9.
Annamalai, A.K., F. Hoveyda, R.M. Williams, A. Patterson and H.L. Simpson, Hyperreactio luteinalis. Qjm, 2011. 104(9): p. 807-8.
Williams, R.M. and D.B. Dunger, Management of polycystic ovary syndrome through puberty and adolescence, in Current Management of Polycystic Ovary Syndrome A. Balen, et al., Editors. 2010, RCOG Press: London.
Williams, R.M., A. Deeb, K.K. Ong, W. Bich, P.R. Murgatroyd, et al., Insulin sensitivity and body composition in children with classical and nonclassical congenital adrenal hyperplasia. Clin Endocrinol (Oxf), 2010. 72(2): p. 155-60.
Semple, R.K., R.M. Williams and D.B. Dunger, What is the best management strategy for patients with severe insulin resistance? Clin Endocrinol (Oxf), 2010. 73(3): p. 286-90.
Regan, F.M., R.M. Williams, A. McDonald, A.M. Umpleby, C.L. Acerini, et al., Treatment with recombinant human insulin-like growth factor (rhIGF)-I/rhIGF binding protein-3 complex improves metabolic control in subjects with severe insulin resistance. J Clin Endocrinol Metab, 2010. 95(5): p. 2113-22.
Lek, N., P. Prentice, R.M. Williams, K.K. Ong, G.A. Burke, et al., Risk factors for obesity in childhood survivors of suprasellar brain tumours: a retrospective study. Acta Paediatr, 2010. 99(10): p. 1522-6.
Salgin, B., A.J. Sleigh, R.M. Williams, S.J. Jackson, L.J. Bluck, et al., Intramyocellular lipid levels are associated with peripheral, but not hepatic, insulin sensitivity in normal healthy subjects. Clin Sci (Lond), 2009. 117(3): p. 111-8.
Salgin, B., M.L. Marcovecchio, R.M. Williams, S.J. Jackson, L.J. Bluck, et al., Effects of growth hormone and free fatty acids on insulin sensitivity in patients with type 1 diabetes. J Clin Endocrinol Metab, 2009. 94(9): p. 3297-305.
Williams, R.M., A. McDonald, M. O'Savage and D.B. Dunger, Mecasermin rinfabate: rhIGF-I/rhIGFBP-3 complex: iPLEX. Expert Opin Drug Metab Toxicol, 2008. 4(3): p. 311-24.
Iles, R., R.M. Williams, A. Deeb, R. Ross-Russell and C.L. Acerini, A longitudinal assessment of the effect of inhaled fluticasone propionate therapy on adrenal function and growth in young children with asthma. Pediatr Pulmonol, 2008. 43(4): p. 354-9.
Almerie, M.Q., R.M. Williams and C.L. Acerini, Should Angiotensin converting enzyme inhibitors be used in children with type 1 diabetes and microalbuminuria? Arch Dis Child, 2008. 93(7): p. 633-5.
McDonald, A., R.M. Williams, F.M. Regan, R.K. Semple and D.B. Dunger, IGF-I treatment of insulin resistance. Eur J Endocrinol, 2007. 157 Suppl 1: p. S51-6.
Williams, R.M., K. Yuen, D. White, B. Mallard, R.N. Dalton, et al., Short-term suppression of elevated growth hormone concentrations following insulin-like growth factor 1 administration in young adults with type 1 diabetes does not alter glomerular filtration or albumin excretion rates. Clin Endocrinol (Oxf), 2006. 65(4): p. 439-45.
Williams, R.M. and D.B. Dunger, Insulin, in Paediatric Clinical Pharmacology, E. Jacqz-Aigrain, Editor. 2006, Taylor and Francis.
Saukkonen, T., F. Shojaee-Moradie, R.M. Williams, R. Amin, K.C. Yuen, et al., Effects of recombinant human IGF-I/IGF-binding protein-3 complex on glucose and glycerol metabolism in type 1 diabetes. Diabetes, 2006. 55(8): p. 2365-70.
Salgin, B., R. Amin, K. Yuen, R.M. Williams, P. Murgatroyd, et al., Insulin resistance is an intrinsic defect independent of fat mass in women with Turner's syndrome. Horm Res, 2006. 65(2): p. 69-75.
Amin, R., R.M. Williams, J. Frystyk, M. Umpleby, D. Matthews, et al., Increasing urine albumin excretion is associated with growth hormone hypersecretion and reduced clearance of insulin in adolescents and young adults with type 1 diabetes: the Oxford Regional Prospective Study. Clin Endocrinol (Oxf), 2005. 62(2): p. 137-44.
Williams, R.M. and D.B. Dunger, Insulin treatment in children and adolescents. Acta Paediatr, 2004. 93(4): p. 440-6.
Saukkonen, T., R. Amin, R.M. Williams, C. Fox, K.C. Yuen, et al., Dose-dependent effects of recombinant human insulin-like growth factor (IGF)-I/IGF binding protein-3 complex on overnight growth hormone secretion and insulin sensitivity in type 1 diabetes. J Clin Endocrinol Metab, 2004. 89(9): p. 4634-41.
George, S., J.J. Rochford, C. Wolfrum, S.L. Gray, S. Schinner, et al., A family with severe insulin resistance and diabetes due to a mutation in AKT2. Science, 2004. 304(5675): p. 1325-8.
Williams, R.M., R. Amin, F. Shojaee-Moradie, A.M. Umpleby, C.L. Acerini, et al., The effects of a specific growth hormone antagonist on overnight insulin requirements and insulin sensitivity in young adults with Type 1 diabetes mellitus. Diabetologia, 2003. 46(9): p. 1203-10.
Savage, D.B., G.D. Tan, C.L. Acerini, S.A. Jebb, M. Agostini, et al., Human metabolic syndrome resulting from dominant-negative mutations in the nuclear receptor peroxisome proliferator-activated receptor-gamma. Diabetes, 2003. 52(4): p. 910-7.
Potau, N., R. Williams, K. Ong, C. Sanchez-Ufarte, F. de Zegher, et al., Fasting insulin sensitivity and post-oral glucose hyperinsulinaemia related to cardiovascular risk factors in adolescents with precocious pubarche. Clin Endocrinol (Oxf), 2003. 59(6): p. 756-62.
Buck, J.J., R.M. Williams, I.A. Hughes and C.L. Acerini, In-utero androgen exposure and 2nd to 4th digit length ratio-comparisons between healthy controls and females with classical congenital adrenal hyperplasia. Hum Reprod, 2003. 18(5): p. 976-9.
Williams, R.M., S.J. O'Toole and A.F. Azmy, Bladder diverticulum causing urethral obstruction in an infant BJU International, 2001. 88: p. 299.
Acerini, C.L., R.M. Williams and D.B. Dunger, Metabolic impact of puberty on the course of type 1 diabetes. Diabetes Metab, 2001. 27(4 Pt 2): p. S19-25.
Rose, A., R.J. Lee, R.M. Williams, L.C. Thomson and A. Forsyth, Functional instability in non-contact ankle ligament injuries. Br J Sports Med, 2000. 34(5): p. 352-8.
International Consensus Statement for the management of children with lipodystrophy (expected 2016)