Dr Liz Hook
MA PHD
University Lecturer in Cellular and Molecular Pathology, Director of Studies for Medicine (Clinical - Year 5)
I hold overall responsibilty for the organisation, delivery and examination of the Clinical Pathology Course in Cambridge. As well as being Senior Examiner for Pathology for Years 4, 5 and 6 of the Cambridge Medical Course, I also lead on the Year 5 written assessments for the Final MB Part II. I have a significant interest in medical education, in particular in the use of learning technology to enhance pathology learning.
I provide clinical sessions in paediatric histopathology at CUHNHSFT. My particular fields of interest are solid and haematological paediatric neoplasms. I am joint training lead for the Histopathology Registrars at Addenbrooke’s Hospital.
Medical Education in Pathology, Educational uses of Technology, Paediatric Cancer
Undergraduate Pathology, Pathological Basis of Clinical Practice, Paediatric Histopathology.
At Homerton, I supervise MedST 1A Histology, MedST/NST 1B Biology of Disease and Clinical Pathology.
2019 University of Cambridge Pilkington Prize for Excellence in Teaching
2017 Clin Soc Excellent Teaching Award
Lingual Alveolar Soft Part Sarcoma in a 1-Year-Old Infant: Youngest Reported Case With Characteristic ASPSCR1-TFE3 Fusion.
Ruffle A, Cameron, M, Jonas N, Levine S, Hook CE, Murray MJ
Pediatr Dev Pathol. 2019 Feb 11:1093526619830290. doi: 10.1177/1093526619830290
PMID: 30744536
Solitary lesion of a newborn's foot.
Maslin D, Hook L, Burrows N.
Pediatr Dermatol. 2018 Jul;35(4):523-524. doi: 10.1111/pde.13505. No abstract available.
PMID: 29984860
Anaplastic large cell lymphoma arises in thymocytes and requires transient TCR expression for thymic egress.
Malcolm TI, Villarese P, Fairbairn CJ, Lamant L, Trinquand A, Hook CE, Burke GA, Brugières L, Hughes K, Payet D, Merkel O, Schiefer AI, Ashankyty I, Mian S, Wasik M, Turner M, Kenner L, Asnafi V, Macintyre E, Turner SD.
Nat Commun. 2016 Jan 12;7:10087. doi: 10.1038/ncomms10087.
PMID: 26753883
Cold antibody autoimmune haemolytic anaemia in a child with diffuse large B cell lymphoma.
Uzunova L, Hook CE, Gattens M, Burke GA.
Ann Hematol. 2016 Jan;95(1):151-2. doi: 10.1007/s00277-015-2498-5. No abstract available.
PMID: 26365160
Funisitis is associated with adverse neonatal outcome in low-risk unselected deliveries at or near term.
Jessop FA, Lees CC, Pathak S, Hook CE, Sebire NJ.
Virchows Arch. 2016 Apr;468(4):503-7. doi: 10.1007/s00428-015-1899-0.
PMID: 26868144
Anaplastic large cell lymphoma-propagating cells are detectable by side population analysis and possess an expression profile reflective of a primitive origin.
Moti N, Malcolm T, Hamoudi R, Mian S, Garland G, Hook CE, Burke GA, Wasik MA, Merkel O, Kenner L, Laurenti E, Dick JE, Turner SD.
Oncogene. 2015 Apr 2;34(14):1843-52. doi: 10.1038/onc.2014.112.
PMID: 24814516
Biallelic somatic SMARCA4 mutations in small cell carcinoma of the ovary, hypercalcemic type (SCCOHT).
Bailey S, Murray MJ, Witkowski L, Hook E, Hasselblatt M, Crawford R, Foulkes WD, Tischkowitz M, Nicholson JC.
Pediatr Blood Cancer. 2015 Apr;62(4):728-30. doi: 10.1002/pbc.25279. Epub 2014 Oct 12.
PMID: 25307865
Umbilical cord coiling: clinical outcomes in an unselected population and systematic review.
Jessop FA, Lees CC, Pathak S, Hook CE, Sebire NJ.
Virchows Arch. 2014 Jan;464(1):105-12. doi: 10.1007/s00428-013-1513-2. Review.
PMID: 24259031
A rare case of neonatal intussusception caused by cytomegalovirus.
Ma R, Alam M, Pacilli M, Hook E, Nagy A, Carroll D.
Eur J Pediatr Surg. 2014 Apr;24(2):184-6. doi: 10.1055/s-0032-1330846. Epub 2012 Nov 21
PMID: 23172560
Auto-immune cholangiopathy in a juvenile patient with systemic lupus erythematosus.
Noble-Jamieson G, Jayne D, Hook E.
Acta Paediatr. 2012 Jun;101(6):e262-4. doi: 10.1111/j.1651-2227.2012.02611.x. Epub 2012 Feb 18.
PMID: 22277082
Determining the contribution of NPM1 heterozygosity to NPM-ALK-induced lymphomagenesis.
Mduff FK, Hook CE, Tooze RM, Huntly BJ, Pandolfi PP, Turner SD.
Lab Invest. 2011 Sep;91(9):1298-303. doi: 10.1038/labinvest.2011.96. Epub 2011 Jun 27.
PMID: 21709672
Relationship between placental morphology and histological findings in an unselected population near term.
Pathak S, Sebire NJ, Hook L, Hackett G, Murdoch E, Jessop F, Lees C.
Virchows Arch. 2011 Jul;459(1):11-20. doi: 10.1007/s00428-011-1061-6. Epub 2011 Apr 12.
PMID: 21484432
Hyperkeratotic papules in a child with Down syndrome. Diagnosis: acquired reactive perforating collagenosis in Down syndrome.
Hafiji J, Hook CE, Burrows NP.
Pediatr Dermatol. 2011 Jan-Feb;28(1):53-4. doi: 10.1111/j.1525-1470.2010.01368.x. No abstract available.
PMID: 21276053
Identification of microRNAs From the miR-371~373 and miR-302 clusters as potential serum biomarkers of malignant germ cell tumors.
Murray MJ, Halsall DJ, Hook CE, Williams DM, Nicholson JC, Coleman N.
Am J Clin Pathol. 2011 Jan;135(1):119-25. doi: 10.1309/AJCPOE11KEYZCJHT.
PMID: 21173133
Cord coiling, umbilical cord insertion and placental shape in an unselected cohort delivering at term: relationship with common obstetric outcomes.
Pathak S, Hook E, Hackett G, Murdoch E, Sebire NJ, Jessop F, Lees C.
Placenta. 2010 Nov;31(11):963-8. doi: 10.1016/j.placenta.2010.08.004. Epub 2010 Sep 15.
PMID: 20832856
Placental weight, digitally derived placental dimensions at term and their relationship to birth weight.
Pathak S, Jessop F, Hook L, Sebire NJ, Lees CC.
J Matern Fetal Neonatal Med. 2010 Oct;23(10):1176-82. doi: 10.3109/14767051003615434.
PMID: 20196636
Castleman's disease in childhood: a surgically curable mimic of autoimmune disease.
Eleftheriou D, Amin T, Hook CE, Auchterlonie I, Houlsby WT, Denison A, Rosendhal K, Davidson JE, Klein N, Brogan PA.
Rheumatology (Oxford). 2008 Sep;47(9):1435-6. doi: 10.1093/rheumatology/ken285. Epub 2008 Jul 22. No abstract available.
PMID: 18647798
Spontaneous regression of an EBV-associated monoclonal large B cell proliferation in the mastoid of a young child following surgical biopsy.
McCabe MG, Hook CE, Burke GA.
Pediatr Blood Cancer. 2008 Oct;51(4):557-9. doi: 10.1002/pbc.21637.
PMID: 18523988
Infection of epithelial and dendritic cells by Chlamydia trachomatis results in IL-18 and IL-12 production, leading to interferon-gamma production by human natural killer cells.
Hook CE, Matyszak MK, Gaston JS.
FEMS Immunol Med Microbiol. 2005 Aug 1;45(2):113-20. Epub 2005 Mar 24.
PMID: 16051062
Effects of Chlamydia trachomatis infection on the expression of natural killer (NK) cell ligands and susceptibility to NK cell lysis.
Hook CE, Telyatnikova N, Goodall JC, Braud VM, Carmichael AJ, Wills MR, Gaston JS.
Clin Exp Immunol. 2004 Oct;138(1):54-60.
PMID: 15373905
Pathology
